FORMULASI TABLET KUNYAH EKSTRAK ETANOL KULIT BUAH NAGA SUPER MERAH (Hylocereus costaricensis) SEBAGAI ANTIOKSIDAN DENGAN KOMBINASI MANITOL DAN POLIVINILPIROLIDON SECARA GRANULASI KERING

FARINDA, Finda (2015) FORMULASI TABLET KUNYAH EKSTRAK ETANOL KULIT BUAH NAGA SUPER MERAH (Hylocereus costaricensis) SEBAGAI ANTIOKSIDAN DENGAN KOMBINASI MANITOL DAN POLIVINILPIROLIDON SECARA GRANULASI KERING. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Waste of super red dragon fruit peel (Hylocereus costaricensis) is rich of betasianin can be profitted as antioxidants source. Super red dragon fruit peel was extracted using 70% ethanol. Ethanol extract super red dragon fruit peel was formulated chewable tablet in dry granulation. The aim of this research was to determine the effect of mannitol and polyvinylpyrrolidone toward physical characteristics, taste chewablet tablet and antioxidants activity (IC50) from each formula chewable tablets. This research uses five formulas with concentration of polyvinylpyrrolidone-mannitol 1%:42%; 2%:41%; 3%:40%; 4%:39%; and 5%:38%; added a formula of negative control without extract. The analysis was conducted at three levels; granule physical evaluation, tablet physical evaluation, taste responses test, and antioxidants analysis using DPPH method. Data were analyzed by one way ANOVA method with 95% confidence interval followed by Post Hoc Test. The result showed that the increase polyvinylpyrrolidone concentration causes decreasing flow time granules, increasing tablet hardness, and decreasing friability. The more adding mannitol causes chewable tablet taste sweeter and preferably respondents. Antioxidants activity of extract super red dragon fruit peel is got value IC50331,513 ppm, IC50 formula 1 (negative control), formula 2; 3; 4; 5 and formula 6 in succession is 5022,269 ppm; 340,669 ppm; 342,937 ppm; 353,119 ppm; 354,573 ppm;and366,956 ppm. Key word : Hylocereus costaricensis, chewable tablet, antioxidants, mannitol, polivinilpirolidon, DPPH

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Hylocereus costaricensis, chewable tablet, antioxidants, mannitol, polivinilpirolidon, DPPH
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:35
Last Modified: 01 Oct 2019 03:35
URI: http://repository.setiabudi.ac.id/id/eprint/1549

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