PENGARUH PEMBERIAN EKSTRAK BUAH KRANGEAN (Litsea cubeba (Lour) Persoon) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL SERUM DARAH TIKUS PUTIH JANTAN

NURROHMAH, Amri Ratnasari (2015) PENGARUH PEMBERIAN EKSTRAK BUAH KRANGEAN (Litsea cubeba (Lour) Persoon) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL SERUM DARAH TIKUS PUTIH JANTAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Hypercholesterolemia is characterized by the increase level of LDL and total cholesterol. Hypercholesterolemia can develop into atherosclerosis and coronary heart disease. Krangean fruit (Litsea cubeba (Lour.) Pers.) contains alkaloid, flavonoid, saponnin and tannin. Flavonoids and saponnins can reduce blood cholesterol and prevents the oxidation of cholesterol in the body. This study was aimed to determine the effect and effective dose of krangean fruit extract on reducing total cholesterol of blood serum in male white mouse. This study used remaceration method with etanol. Animals test used 25 male white mice that were divided into 5 groups, i.e. normal group (without treatment), hypercholesterol group (CMC 1%), krangean fruit ethanol extract with dose 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. All of these animals test except normal group were made hypercholesterol with high fat diet for 14 days. Total cholesterol levels of these animals test were measured on day 7, day 21, day 28 by CHOD-PAP method. The result of this study showed that krangean fruit extract could reduced total cholesterol of blood serum in male white mouse. The most effective dose on reducing total cholesterol of blood serum in male white mouse was 400 mg/kg BW. Keywords : Krangean fruit, Litsea cubeba (Lour.) Pers., hypercholesterolemia, high fat diet.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Krangean fruit, Litsea cubeba (Lour.) Pers., hypercholesterolemia, high fat diet.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:33
Last Modified: 01 Oct 2019 03:33
URI: http://repository.setiabudi.ac.id/id/eprint/1527

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