OPTIMASI TABLET FLOATING PROPRANOLOL HIDROKLORIDA MENGGUNAKAN ETIL SELULOSA DAN ASAM SITRAT TERHADAP KEMAMPUAN MENGAPUNG DAN PELEPASAN OBAT DENGAN METODE FACTORIAL DESIGN

AGUSTINA, Sufia Wahyu (2016) OPTIMASI TABLET FLOATING PROPRANOLOL HIDROKLORIDA MENGGUNAKAN ETIL SELULOSA DAN ASAM SITRAT TERHADAP KEMAMPUAN MENGAPUNG DAN PELEPASAN OBAT DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Propranolol HCl is a non-selective β-adrenergic receptor that has been used to treat hypertension and angina pectoris. Propranolol HCl is well absorbed in stomach with half-life about 3-6 hours, thus need to be formulated in sustained released dosage form that can retain the dosage form in the stomach (GRDDS) to improve its bioavailability, reduced frequency of use, and prolong the drug release. GRDDS dosage form is formulated by floating system. This study was purposed to optimize and evaluate the influence of ethyl cellulose and citric acid on physical properties and found out drug release kinetics and mechanism of propranolol HCl tablet with floating system. Factorial design method was used to optimize the floating propranolol HCl tablet using ethyl cellulose and citric acid as independent variables. Superimposed contour plot was determined an optimum area on several parameters i.e. hardness, floating lag time, swelling index, Q60, Q180, and Q300 by Design Expert® software version 7.1.5. Citric acid was factor that reduced the floating lag time and total floating time, although increased the swelling index and drug release. An increase ethyl cellulose increased floating lag time and reduced swelling index and drug release. Weibull model described the drug release kinetics and the mechanism of drug release was diffusion and non-Fickian diffusion. The optimum area based on superimposed contour plot was citric acid and ethyl cellulose of 32.0 and 78.85 mg, respectively. Keywords : citric acid, ethyl cellulose, factorial design, floating lag time, floating system, GRDDS, floating propranolol HCl tablet, total floating time

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: citric acid, ethyl cellulose, factorial design, floating lag time, floating system, GRDDS, floating propranolol HCl tablet, total floating time
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:28
Last Modified: 01 Oct 2019 03:28
URI: http://repository.setiabudi.ac.id/id/eprint/1487

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