OPTIMASI FDT NIFEDIPIN YANG TERDISPERSI PEG 6000 DENGAN KOMBINASI SUPERDISINTEGRANT CROSPOVIDONE DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN

PRASETYO, Sudarmanto Trisno Bagus (2016) OPTIMASI FDT NIFEDIPIN YANG TERDISPERSI PEG 6000 DENGAN KOMBINASI SUPERDISINTEGRANT CROSPOVIDONE DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Nifedipine is a calcium channel blocker. Nifedipine is a drug that is poorly soluble in water and is a class of drugs known as BCS 2. Limitations of this compound can be overcome by making the preparation of fast disintegrating tablet that has been dispersed PEG 6000. The purpose of this study was to optimized the combination of superdisintegrant crosspovidone and effervescent component of the quality of physical and drug release of nifedipine by using a factorial design method. The method of making fast disintegrating tablet nifedipine dispersed PEG 6000 using direct compression method. The optimization process is done by using a factorial design optimization methods, with factors such as crosspovidone and effervescent component. The resulting tablets were tested physical quality granule, tablet physical quality, and drug release. Results will be analyzed using Design Expert 6.0.8 trial version based on the critical point of hardness, friability, disintegration time in-vitro, in-vivo disintegration time, wetting time, taste test response and the amount of drugs apart for 1 minute. The results showed that combination of crosspovidone and effervescent component produced hardness 3,7 kg, disintegration time in-vitro 9,66 sec, friability 0,72%, wetting time 34,16 sec, disintegration time in-vivo 10,75 sec, Q1 63,54%, DE30 70,06% and given moderate taste. Superimposed optimization based on the results obtained optimum formula counter plot FDT nifedipine dispersed PEG 6000 with a combination of 2.58% crosspovidone superdisintegrant and effervescent component by 3%. Keyword : fast disintegrating tablet that has been dispersed PEG 6000, crosspovidone, effervescent, factorial design.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: fast disintegrating tablet that has been dispersed PEG 6000, crosspovidone, effervescent, factorial design.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:27
Last Modified: 01 Oct 2019 03:27
URI: http://repository.setiabudi.ac.id/id/eprint/1486

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