UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN IRITASI AKUT DERMAL GEL EKSTRAK ETANOLIK DAUN JARAK (Ricinus communis L.) PADA KELINCI GALUR NEW ZEALAND

ULA, Siti Fadhilatul (2016) UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN IRITASI AKUT DERMAL GEL EKSTRAK ETANOLIK DAUN JARAK (Ricinus communis L.) PADA KELINCI GALUR NEW ZEALAND. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Castor leaves (Ricinus communis L.) contains alkaloid, flavonoid and saponin were allegedly capable to heal burns. This study aimed to determine whether the gel castor leaves ethanolic extract can heal burns and has side effects irritate the skin of rabbit of New Zealand strain. Gel castor leaves extract was made in formulas 2 %, 4 % and 8 %. Physical stability was tested organoleptic, homogenity, pH, viscosity, dispersion and adhesion. Activity of burns healing and acute dermal irritation was conducted at back of rabbit New Zealand strain. Burn healing measurement results were analyzed statistically using variance analysis to know difference on 21th day. Acute dermal irritation results were made table and calculated primary irritation index. Gel castor leaves extract qualified physical stability test gel formulation included organoleptic test, homogenity, pH, viscosity, dispersion and adhesion. Administration of gel castor leaves extract with a concentration of 2 %, 4 %, 8 % give effect to the healing of burns. Gel castor leaves extract does not cause irritation such as erythema and edema on the skin of rabbit of New Zealand strain with primary irritation index on third formulas included in the category of very slight (negligible). Keywords: gel, castor leaves, burns, physical stability, rabbit

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: gel, castor leaves, burns, physical stability, rabbit
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:27
Last Modified: 01 Oct 2019 03:27
URI: http://repository.setiabudi.ac.id/id/eprint/1483

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