OPTIMASI PROPORSI FAST DISINTEGRATING TABLET PIROKSIKAM DENGAN KOMBINASI SUPERDISINTEGRANT CROSPOVIDONE DAN BAHAN EFFERVESCENT DENGAN METODE SIMPLEX LATICE DESIGN

ADHAWIYAH, Robi’ah (2016) OPTIMASI PROPORSI FAST DISINTEGRATING TABLET PIROKSIKAM DENGAN KOMBINASI SUPERDISINTEGRANT CROSPOVIDONE DAN BAHAN EFFERVESCENT DENGAN METODE SIMPLEX LATICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Piroxicam is a NSAID with oksikam structure. Piroxicam are drugs that have low solubility, thus requiring a long time to achieve the desired effect. Methods of fast disintegrating tablet can help speed up the effects. Fast disintegrating tablets piroxicam made methods SLD consists of three formulas with variations of comparison, the first formula of 100% Crospovidone: 0% component of the effervescent, second formula of 50% Crospovidone: 50% of the components effervescent, and formula three 0% Crospovidone: 100% component of the effervescent , The third formula is printed with direct forged and tested methods of physical quality of physical properties of powders and tablets and then responsive falvour test. The test results later in the optimization of physical properties with Simplex Latice Design program, using the parameters of the critical point, namely hardness, friability, disintegration time in vivo, in vitro disintegration time, wetting time,dissolution Q1, and DE5. Effervescent component concentration variation and crospovidone affect the critical point. Crospovidone combination with effervescent component can accelerate disintegration time and provide a sense of fun. Optimization results fast disintegrating tablet piroxicam obtained optimum formula by comparison Crospovidone 18.68%: 81.32% effervescent component to the desirability 0.688. The test results of the optimization validation using One Sample T-test with a level of 95%. The optimum formula validation results obtained sig. > 0.05 so do not differ meaningfully. Keywords: Piroxicam, fast disintegrating tablet, crospovidone, effervescent, Simplex Latice Design.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Piroxicam, fast disintegrating tablet, crospovidone, effervescent, Simplex Latice Design.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:25
Last Modified: 01 Oct 2019 03:25
URI: http://repository.setiabudi.ac.id/id/eprint/1472

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