OPTIMASI FORMULA FDT NIFEDIPIN YANG TERDISPERSI PEG 6000 MENGGUNAKAN KOMBINASI SUPERDISINTEGRANT EXPLOTAB DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN

IMANINGTYAS, Ririn Devanti (2016) OPTIMASI FORMULA FDT NIFEDIPIN YANG TERDISPERSI PEG 6000 MENGGUNAKAN KOMBINASI SUPERDISINTEGRANT EXPLOTAB DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Nifedipine as a calcium antagonist used for hypertension therapy. Nifedipine is a drug that is poorly soluble in water an is a class of drugs known as BCS 2. Nifedipine dispersed with PEG 6000 to increase the solubility. Nifedipine that dispersed PEG 6000 were made in the preparation of fast-disintegrating tablet (FDT) which can disintegrate quickly in the mouth without water and can provide immediate effect. This research aims to optimize effect of the combination explotab and effervescent component of physical tablet properties and drug release by factorial design method. Factorial design method is used to optimize tablets with explotab factors and effervescent component. Tablets made by direct compression method and tested physical properties of powders and tablets and drug release. Optimum area determined by superimposed contour plot using Design Expert 8.0.6 trial version software based on parameters hardness, friability, disintegration time in-vitro, invivo disintegration time, wetting time, the amount of drug released for 1 minute, 30 minutes Dissolution efficiency. Factors explotab give more dominant effect on increasing hardness, disintegration time and the in-vitro drug release compared of effervescent component. Interaction between explotab and effervescent component can increase hardness, disintegration time in-vitro, and wetting time. Based on superimposed contour plots obtained nifedipine FDT tablet formulation by combination explotab 16 mg and effervescent component 15,52 mg, which provides medium sweetness effect. Keywords: FDT nifedipine that has been dispersed PEG 6000, explotab, effervescent component, factorial design.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: FDT nifedipine that has been dispersed PEG 6000, explotab, effervescent component, factorial design.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:24
Last Modified: 01 Oct 2019 03:24
URI: http://repository.setiabudi.ac.id/id/eprint/1468

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