EFEK SARI BUAH TERONG BELANDA (Cyphomandra betacea Sendtn.) TERHADAP AKTIVITAS ENZIM ALT DAN AST TIKUS PUTIH JANTAN YANG DIINDUKSI ISONIAZID DAN RIFAMPISIN

RAHMI, Rahmi (2016) EFEK SARI BUAH TERONG BELANDA (Cyphomandra betacea Sendtn.) TERHADAP AKTIVITAS ENZIM ALT DAN AST TIKUS PUTIH JANTAN YANG DIINDUKSI ISONIAZID DAN RIFAMPISIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Tree tomato contains antioxidants such as vitamin C, vitamin E, anthocyanins, and beta carotene. Antioxidants activity are important to protection the liver cells of toxic substances. The aims of this study were determine the effect of tree tomato juice to ALT and AST activity in male white rats induced by isoniazid and rifampicin. The thirty rats were devide into six groups. The normal control were given CMC 0,5%; negative control were given isoniazid 50 mg /kg BW and rifampicin 50 mg /kg BW, positive control were given isoniazid, rifampicin and Methicol® 22,5 mg /kg BW, and the treatment groups were given isoniazid, rifampicin and tree tomato juice on various doses (17,5 g /kg BW, 35 g /kg BW dan 70 g /kg BW). Each group were given every day for 21 days. The activity of ALT and AST were determined on 0th, 7th, 14th and 21th day. Data were analyzed by Two-Way ANOVA and Post Hoc LSD Test. The result of statistic showed significant difference of average decrease in ALT and AST activity between the treatment groups. Provision of tree tomato juice can prevents increased the activity of ALT and AST. The best doses was 70 g /kg BW. Keywords: Cyphomandra betacea Sendtn., isoniazid, rifampicin, ALT, AST

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Cyphomandra betacea Sendtn., isoniazid, rifampicin, ALT, AST
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:22
Last Modified: 01 Oct 2019 03:22
URI: http://repository.setiabudi.ac.id/id/eprint/1455

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