UJI AKTIVITAS ANTIARTHRITIS KOMBINASI EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) DAN TRIAMSINOLON PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND’S ADJUVANT (CFA)

Noviyati K.S, Noviyati K.S (2016) UJI AKTIVITAS ANTIARTHRITIS KOMBINASI EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) DAN TRIAMSINOLON PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND’S ADJUVANT (CFA). Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Arthritis is a desease which attack joints and structure arround the joint. An avocado seed (Persea americana Mill) and triamsinolon is one of the plants and medicine which can be used for inflamation and arthritis. This study aim to determine the antiarthritis effect and hispatological profile from a given of combination avocado seed and triamsinolon in male rats induced Complete Freund’s Adjuvant (CFA). An animal test induced CFA 0,2 ml then treatment was given for 7 days, udem volume was measured everyday. The first group is given a extract of avocado seed (392 mg/kg BB), second group until fourth is given a combination of avocado seed and triamsinolon (0,054 mg/ Kg BB: 98 mg/ Kg BB), (0,036 mg/ Kg BB : 196 mg/ Kg BB), (294 mg/ Kg BB : 0,018 mg/ Kg BB), the fifth group is given a triamsinolon, the sixth group is given CMC 0,5%. Parameter measured were decrease in edema volume and joint histopathology profile. The result showed combination of avocado seed extract and triamsinolon gave an antiarthritis effect was not significant with single dosage. The percent improvement of highest edema volume is the combination of an avocado seed and triamsinolon (0,036 mg/ Kg BB : 196 mg/ Kg BB). Single dosage extract along with the combination of avocado seed etanol extract and triamsinolon can increase the percent derivation udem volume and improvement hispatology profile. Key words : Persea americana Mill, triamsinolon, Complete Freund’s Adjuvant (CFA), ekstrak etanol, antiarthritis.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Persea americana Mill, triamsinolon, Complete Freund’s Adjuvant (CFA), ekstrak etanol, antiarthritis.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:19
Last Modified: 01 Oct 2019 03:19
URI: http://repository.setiabudi.ac.id/id/eprint/1433

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