UJI TOKSISITAS SUBKRONIK SINGKAT EKSTRAK ETANOLIK AKAR JARAK (Ricinus communis Linn.) TERHADAP ORGAN GINJAL TIKUS GALUR WISTAR

KARTIKASARI, Ma’in Noor (2016) UJI TOKSISITAS SUBKRONIK SINGKAT EKSTRAK ETANOLIK AKAR JARAK (Ricinus communis Linn.) TERHADAP ORGAN GINJAL TIKUS GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Ricinus roots have antiasthma effect, which contain saponins and flavonoids, that can inhibit histamine in anafilaksis reaction. Study of acute toxicity has been done, so that necessary study of subchronic toxicity. The research goals are know the long effect in kidney. This research conducted 25 males and females wistar rats, divided into 5 groups, they are control, group I, II, III, and satellite that given PGA, 100, 500, 1000 and 1000 mg/kgWeight respectively. The parameter are body weight, chemical blood e.g BUN & chreatinin and histopatologic organ. The extract are given everyday for 28 days and sampling did once a week. Than all of groups was surge, except the satellite group that surged 14th later. The result of statistic test each parameter are normaly distribution (P>0,05), but that wasn’t homogen because P<0,05. That mean there are significancy differences every dosage and between dosage and gender. The result of kidney histopatologic are high level damage in highest dosage and satellite groups. The conclusion are extract etanolic of ricinus roots given irreversible toxic effect Key Words : root extract Ricinus, short subkronik toxicity tests, weight, BUN, creatinine, histopathology

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: root extract Ricinus, short subkronik toxicity tests, weight, BUN, creatinine, histopathology
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 01 Oct 2019 03:15
Last Modified: 01 Oct 2019 03:15
URI: http://repository.setiabudi.ac.id/id/eprint/1406

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