OPTIMASI FORMULA ORALLY DISINTEGRATING TABLET (ODT) CETIRIZIN HCL MENGGUNAKAN MANITOL DAN AVICEL PH 102 SEBAGAI FILLERBINDER DENGAN METODE SIMPLEX LATTICE DESIGN

SAPUTRA, Dennis (2016) OPTIMASI FORMULA ORALLY DISINTEGRATING TABLET (ODT) CETIRIZIN HCL MENGGUNAKAN MANITOL DAN AVICEL PH 102 SEBAGAI FILLERBINDER DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Cetirizine HCl is an antihistamine drug classes used to treat upper respiratory tract infections. Allergic diseases can occur everyone, so that cetirizine HCl made in Orally Disintegrating tablets that can be easily swallowed by the patient. The purpose of this study was to look at the combined effect of Avicel PH 102 and mannitol as a filler-binders and get the optimum formula in terms of physical quality test tablet and test the response was great. Avicel PH 102 and mannitol used as a filler-binder, it manufactured by direct compression, further optimized by the simplex lattice design. Critical parameters in this research are hardness, friability, in vitro disintegrating time, Q3, DE30 and respondent test. The combination of the two components are made of three formulas, the first formula proportion of Avicel PH 102 and mannitol at 31,65 and 68,35%; The second formula of 50:50% and the third formula amounted to 68,35:31,65%. The combination of Avicel PH 102 and mannitol affect to physical quality of Cetirizine HCl orally disintegrating tablet form. Increasing proportion of Avicel PH 102 improve hardness, dissolution profiles and friability is decreased whereas the increase in the proportion of mannitol accelerate disintegration and wetting time of the tablets. Respondent test showed that all formulas have sweet and a bit bitter taste. After optimization obtained the optimum proportion of Avicel PH 102 and mannitol at 58,45:41,55%. Keywords : ODT Cetirizine HCl, Avicel PH 102, Mannitol, filler-binder, simplex lattice design.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: ODT Cetirizine HCl, Avicel PH 102, Mannitol, filler-binder, simplex lattice design.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 30 Sep 2019 02:22
Last Modified: 30 Sep 2019 02:22
URI: http://repository.setiabudi.ac.id/id/eprint/1340

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