OPTIMASI FORMULA ORALLY DISINTEGRATING TABLETS GLIMEPIRID MENGGUNAKAN KOMBINASI SUPERDISINTEGRAN SODIUM STARCH GLYCOLATE DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN

MUTIARAWATI, Aulina (2016) OPTIMASI FORMULA ORALLY DISINTEGRATING TABLETS GLIMEPIRID MENGGUNAKAN KOMBINASI SUPERDISINTEGRAN SODIUM STARCH GLYCOLATE DAN KOMPONEN EFFERVESCENT DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Glimepiride is a sulfonylurea antidiabetic which it used to treatment of type II diabetes mellitus. Initial dose of glimepiride is 1 to 2 daily and may be increased to 4 mg daily for maintenance. Glimepiride was the drug of choice because of its low dose. Glimepiride orally disintegrating tablets (ODTs) was formulated to reach faster disintegration time in the oral cavity without water needed and furthermore it was intended to give rapid therapeutic action. The aim of this research is to optimize the influence of combination sodium starch glycolate and effervescent components which have function as disintegrant, toward physical properties and drug release with factorial design method. Orally disintegrating tablets were prepared by direct compression method and it was evaluated for physical properties of powder and tablet, and drug release. Optimization the formula was carried out by 22 factorial design method with sodium starch glycolate and effervescent component as independent variables. Optimum formula was determined by superimposed counter plot using sofware Design Expert 9.0.6 trial version based on tablets properties i.e hardness, friability, disintegration time, wetting time, and amount of drug release during 1 minute. This research was found that effervescent components was the most dominant factor had an affect on disintegration time and amount of drug release than sodium starch glycolate. Enhancement effervescent components affected on increase disintegration time of tablet and decrease amount of drug release. Based on superimposed counter plot, optimum formula was achieved with combination sodium starch glycolate 3,27 mg and effervescent components 6,00 mg. Keywords: ODTs, glimepiride, sodium starch glycolate, effervescent components, factorial design.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: ODTs, glimepiride, sodium starch glycolate, effervescent components, factorial design.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 26 Sep 2019 08:31
Last Modified: 26 Sep 2019 08:31
URI: http://repository.setiabudi.ac.id/id/eprint/1323

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