PENGARUH VARIASI KONSENTRASI NATRIUM BIKARBONAT DAN ASAM SITRAT TERHADAP DAYA MENGEMBANG, MENGAPUNG DAN DISOLUSI TABLET FLOATING VERAPAMIL HCl DENGAN METODE FACTORIAL DESIGN

NUGROHO, Adi Bayu (2016) PENGARUH VARIASI KONSENTRASI NATRIUM BIKARBONAT DAN ASAM SITRAT TERHADAP DAYA MENGEMBANG, MENGAPUNG DAN DISOLUSI TABLET FLOATING VERAPAMIL HCl DENGAN METODE FACTORIAL DESIGN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Verapamil HClused to treatment of hypertension. Verapamil HCl has a bioavailability of 20% and half-life of 2 hours so that it can be made preparations gastroretentive to improve the bioavailability and prolong the drug release. The aim of study were knowing infuence of sodium bicarbonate and citric acidon floatation behavior and swelling, and drug released of verapamil HCl floating tablet. The research was using four variation of concentration sodium bicarbonate and citric acidby direct compressiion method and it was evaluated for physical properties of powder and tablet, and drug released. The influence of concentration sodium bicarbonate and citric acid on floatation behavior and swelling, and drug release was determined by sofware Design Expert®. The results showed that sodium bicarbonate affect on decreased of floating lag time, increased of floating time and decreased in drug released. Citric acid affect on the increased of floating lag time and floating time but decreased in drug release. Interaction of sodium bicarbonate and citric acid decreased drug released at the beginning and decreased ability of swelling. High level of sodium bicarbonate and citric acid (70 : 30) had the longest floating time, the fastest floating lag time and the largest ability of swelling and followed zero order. Keyword : verapamil HCl, floating, sodium bicarbonate, citric acid

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: verapamil HCl, floating, sodium bicarbonate, citric acid
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 26 Apr 2019 03:31
Last Modified: 26 Apr 2019 03:31
URI: http://repository.setiabudi.ac.id/id/eprint/1299

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