UJI AKTIVITAS ANTIBAKTERI GEL HAND SANITIZER EKSTRAK ETANOL DAUN STEVIA (Stevia rebaudiana Bertoni) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923

AMARTA, Wisky (2018) UJI AKTIVITAS ANTIBAKTERI GEL HAND SANITIZER EKSTRAK ETANOL DAUN STEVIA (Stevia rebaudiana Bertoni) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Stevia leaves are known to have antibacterial activity against Staphylococcus aureus bacteria. Stevia leaves can not directly kill the bacteria, therefore stevia leaves are extracted first and then formulated into gel preparation hand sanitizer with several types of formula with variation concentration of ethanol extract. The aim of this study was to formulate gel preparation hand sanitizer extract ethanol stevia leaves and to test the physical characteristic, stability, and its activity against bacteria Staphylococcus aureus. Stevia leaves were extracted using a maceration method for 5 days with 70% ethanol solvent. Stevia leaf ethanol extract was formulated into 3 formulas with concentration differences of ethanol extract: 10%, 15%, and 20%. The gel preparation of each formula was tested of its organoleptic, homogeneity, pH, viscosity, dispersion, and adhesion, stability and activity against Staphylococcus aureus bacteria. The data were analyzed statistically using kolmogorov-smirnov test followed by two way anova test. The results of the experiment indicated that the extract of ethanol stevia leaves can be made into gel preparation hand sanitizer and have antibacterial activity. The difference of ethanol extract concentration 10%, 15% and 20% effected on physical characteristic of gel preparation and its stability. Gel hand sanitizers with various concentrations of ethanol extract of stevia leaves have antibacterial activity. Statistical test results on antibacterial activity indicated that the three formulas have significantly different antibacterial activity. Keywords: Stevia rebaudiana Bertoni, ethanol extract, gel hand sanitizer, antibacterial, Staphylococcus aureus.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Stevia rebaudiana Bertoni, ethanol extract, gel hand sanitizer, antibacterial, Staphylococcus aureus.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 25 Feb 2019 03:41
Last Modified: 25 Feb 2019 03:41
URI: http://repository.setiabudi.ac.id/id/eprint/1255

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