FORMULASI PATCH BUCCAL MUCOADHESIVE NIFEDIPIN MENGGUNAKAN KOMBINASI MATRIKS CARBOPOL 940P® DAN HIDROKSI PROPIL METIL SELULOSA (HPMC) K15M

Yudhantara, Sandi Mahesa (2017) FORMULASI PATCH BUCCAL MUCOADHESIVE NIFEDIPIN MENGGUNAKAN KOMBINASI MATRIKS CARBOPOL 940P® DAN HIDROKSI PROPIL METIL SELULOSA (HPMC) K15M. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Nifedipine is calcium antagonist (Calcium Entry Blockers) that used for hypertensive therapy with 2-6 hours of t½. Nifedipine experiences first pass metabolism in oral use, therefore buccal medicine delivery was made using mucoadhesive system that can improve bioavailability and effectiveness of nifedipine. This research is aimed to find the effect of Carbopol® 940P and HPMC K15M concentrations on patch buccal mucoadhesive physical propertys, adhesiveness and removal of nifedipine on patch buccal mucoadhesive. The research used five formulas with varying concentrations of Carbopol® 940P and HPMC K15M. The test was conducted on patch’s physical property, mucoadhesive strength and medicine removal. The analysis on medicine removal was conducted using padlle model of apparatus II USP with 500 mL medium buffer phosphate at pH 6,8 as medium, stirring rate of 50 rpm, the temperature at 37±0,5oC for 6 hours. The result of research showed that varying concentrations of Carbopol® 940P and HPMC K15M affected swelling index, adhesiveness and profile of nifedipine removal on patch buccal mucoadhesive. The increased proportion of HPMC K15M improved the percentage of swelling index, but reduced the amount of medicine removed. The increased proportion of Carbopol® 940P improved the duration of mucoadhesive patch strength. The proportion of Carbopol 940P 30 mg and HPMC K15M 40 mg produced the longest duration of mucoadhesive patch strength. Keywords : mucoadhesive, nifedipin, carbopol® 940P, HPMC K15M

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: mucoadhesive, nifedipin, carbopol® 940P, HPMC K15M
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 03:39
Last Modified: 25 Feb 2019 03:39
URI: http://repository.setiabudi.ac.id/id/eprint/1214

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