FORMULASI DAN KARAKTERISASI S-SNEDDS (Solid SelfNanoemulsifying Drug Delivery System) MELOKSIKAM MENGGUNAKAN AEROSIL DAN CROSPOVIDONE SEBAGAI ADSORBEN DENGAN TEKNIK ADSORPTION TO SOLID CARRIER

MALA, Rifa Choirul (2018) FORMULASI DAN KARAKTERISASI S-SNEDDS (Solid SelfNanoemulsifying Drug Delivery System) MELOKSIKAM MENGGUNAKAN AEROSIL DAN CROSPOVIDONE SEBAGAI ADSORBEN DENGAN TEKNIK ADSORPTION TO SOLID CARRIER. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Meloxicam (MEL) is an enolate class of oxycam derivatives of which its solubility is low in the water and has pharmacological activity to reduce pain as well as inflammation symptoms, but it has lower toxicity than other Anti-Inflammation Medicine (OAINS). Meloxycam pharmacokinetics profile can be converted using SNEDDS formulation with the addition of aerosyl and cropovidone adsorbents to improve their solubility and stability. The optimum formulatory of SNEEDS meloxicam based on previous research with olive oil composition of 0,052 mg, tween 80 equal to 1,826 mg and PEG 400 0,122 mg then made in solid form with additional of aerosil adsorbent and crospovidone by adsorption to solid carrier and characterized based on emulsification time, drug loading,`percent transmitan, particle size, FT-IR, SEM and dissolution test. The result of solid characterization of SNEDDS meloxicam with arosil and crospovidone adsorbents showed emulsification time of 60.17±0.54 second, transmitter percentage by 52.30±1.51 %, and 38.50±1.47, drug loading by 75.22±1.24 ppm and 49,69±0,12, particle size by 122.2 nm with a PDI of 0.476 and 168,1 nm with PDI 0,776. Based on the results of the characterization, aerosil showed better results than crospovidone. The solid dissolution test of SNEEDS meloxicam with aerosyl adsorbent on phosphate buffer with pH 6.8 attains 102.06% in 20 minutes, which it is higher the pure meloxycam by 68.06%. Keywords : meloxycam, solid SNEDDS, adsorption to solid carrier, aerosil, crospovidone

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: meloxycam, solid SNEDDS, adsorption to solid carrier, aerosil, crospovidone
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 25 Feb 2019 03:25
Last Modified: 25 Feb 2019 03:25
URI: http://repository.setiabudi.ac.id/id/eprint/1137

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