PENGARUH KOMBINASI EKSTRAK UBI JALAR UNGU (Ipomoea batatas L.) DAN GLIBENKLAMID TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH JANTAN HIPERGLIKEMIK YANG DIINDUKSI ALOKSAN

Nuraisyah, Riska (2017) PENGARUH KOMBINASI EKSTRAK UBI JALAR UNGU (Ipomoea batatas L.) DAN GLIBENKLAMID TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH JANTAN HIPERGLIKEMIK YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Purple sweet potato (Ipomoea batatas L.) and glibenclamide were trust could decreased blood glucose effectively. The purpose of this study was to determine activity of combination purple sweet potato extract (PSPE) and glibenclamide in lowering blood glucose level of male white rats hyperglicemic induced with alloxan. This research use twenty five rats were divided into 5 groups. Group I was normal control, group II was negative control (CMC 0,5%), group III was positive control (glibenclamide dose of 0,09 mg/200 g BW), group IV was purple sweet potato extract (PSPE) control (dose of 200 mg/kgBW), group V was combination of PSPE : glibenclamide 50%:50% (dose of 0,045 mg/200 g BW : 40 mg/ 200 g BW). Rats were induced with alloxan dose of 140 mg/kg BW intraperitoneally. The rats were treatment for 14 days orally. The measurement of blood glucose at days 0th, 3rd, 7th, 14th after treatment by using glucose oxidase (GOD-PAP) method. Glucose levels data was analyzed with one way ANOVA. The result of glucose levels showed that PSPE and combination of PSPE : glibenclamide (50%:50%) could decreased blood glucose. This combination proportionated with PSPE control, but the potential lower than a single dose of glibenclamide. Keywords: purple sweet potato, glibenclamide, alloxan, blood glucose

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: purple sweet potato, glibenclamide, alloxan, blood glucose
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 03:22
Last Modified: 25 Feb 2019 03:22
URI: http://repository.setiabudi.ac.id/id/eprint/1115

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