UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. & G. Forst) DENGAN PARAMETER KADAR KOLESTEROL TOTAL, TRIGLISERIDA, LDL DAN HDL PADA TIKUS GALUR WISTAR

Kusumaningrum, Putri Rosita Kusumaningrum (2018) UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. & G. Forst) DENGAN PARAMETER KADAR KOLESTEROL TOTAL, TRIGLISERIDA, LDL DAN HDL PADA TIKUS GALUR WISTAR. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Matoa leaf (Pometia pinnata J.R. & G. Forst) acute toxicity test showed LD50 value >5000 mg/kgBB practically not toxic. The ethanolic extract of matoa leaf has activity as antihypertensive. The purpose of this study was to know the subchronic toxicity of ethanol extract of matoa leaf for 90 days dose 150, 500, 1000 mg/kgBW with parameter of total cholesterol, triglyceride, HDL, and LDL. The extract matoa leaf was obtained from maceration process with 70% ethanol. This study used 50 male rats and 50 female rats, divided into 5 groups. The first group of negative control was given 0,5% CMC, treatment group of two to four were prepared with extract matoa leaf doses of 250, 500, 1000 mg/kgBW, and satellite group was given 1000 mg/kgBW. The study was conducted over 90 days and added 28 days in the satellite group. The examination of total cholesterol, triglyceride, HDL and LDL levels was performed on T0, T90, and T118. Subcronic toxicity test results showed that ethanol extract of leaf matoa dose 150, 500, and 1000 mg/kgBB for 90 days against observation of total cholesterol, triglyceride of male and female rats did not give toxic effect, whereas HDL observations have the toxic effect of lowering HDL levels of male and female rats, HDL observation of 150 mg / kgBW effective dose did not produce toxic effects of male and female rats. Doses 150, 500, mg / kgBW did not cause toxic effects of LDL levels of male and female rats. Keywords: Pometia pinnata, subchronic toxicity, total cholesterol, triglyserides, HDL, LDL

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Pometia pinnata, subchronic toxicity, total cholesterol, triglyserides, HDL, LDL
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 25 Feb 2019 03:21
Last Modified: 25 Feb 2019 03:21
URI: http://repository.setiabudi.ac.id/id/eprint/1101

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