OPTIMASI CAMPURAN AMILUM MANIHOT DAN AVICEL PH 101 DALAMPEMBUATAN HOST CAMPURAN INTERAKTIF PREDNISON SECARA SLD DENGAN PENAMBAHANSURFAKTAN PEG 4000

Retmana, Riaya Shelly (2017) OPTIMASI CAMPURAN AMILUM MANIHOT DAN AVICEL PH 101 DALAMPEMBUATAN HOST CAMPURAN INTERAKTIF PREDNISON SECARA SLD DENGAN PENAMBAHANSURFAKTAN PEG 4000. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Prednisone has a poor solubility in water that affects its bioavailability. The interactive mix method is one way to speed up drug solubility by placing the drug in micronized form attached to the host (the carrier). This study aims to determine the effect of combination of amylum filler and avicel PH 101 as a host in the manufacture of an interactive mixture of prednisone tablets. The optimum proportion of amylum filler and avicel PH 101 Will provide the physical quality and dissolution profile of an interactive mixture of prednisone. The study was conducted with 3 variations of the filler with the proportion of 100% (93,5 mg) avicel PH 101: 0% (0 mg) amylum; 50% (46.75 mg) avicel PH 101: 50% (46.75 mg) amylum and 0% (0 mg) avicel PH 101: 100% (97.5 mg) amylum. Each formulae was subject to the process of tableting and examination toward its critical point of fragility, time of disintegration and dissolution. The result was then analyzed by using simplex lattice design to meet the optimum formulae. The study results in the optimum formula, that the proportion of avicel PH 101 is greater than that of 82.654 mg: 10.846 mg, alu fragmentation is equal to 0.91%, crushed time 3.16 minutes and dissolution of Q30 103.35%. Kata Kunci : Prednisone, Interactive mixture, Host, simplex lattice design

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Prednisone, Interactive mixture, Host, simplex lattice design
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 03:20
Last Modified: 25 Feb 2019 03:20
URI: http://repository.setiabudi.ac.id/id/eprint/1094

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