EFEK EKSTRAK ETANOL KULIT BATANG FALOAK (Sterculia quadrifida R.Br) TERHADAP RADIKAL BEBAS DPPH (in vitro) DAN AKTIVITAS ENZIM GLUTATION PEROKSIDASE PADA TIKUS DIABETES

Praing, Rambu Konda Anggung (2017) EFEK EKSTRAK ETANOL KULIT BATANG FALOAK (Sterculia quadrifida R.Br) TERHADAP RADIKAL BEBAS DPPH (in vitro) DAN AKTIVITAS ENZIM GLUTATION PEROKSIDASE PADA TIKUS DIABETES. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Faloak bark (Sterculia quadrifida R.Br) is the part of faloak tree which has antioxidant and antidiabetic activity. The purpose of this study is to know the antioxidant effect of faloak bark by in vitro and in vivo method. Ethanolic extract of faloak bark is tested to the antioxidant activity by bind the free radical DPPH method (in vitro) with IC50 parameter and using rutin as standard to compare with the extract. Antioxidant activity test (in vivo) in this study using increased activity of glutathion peroxidase enzyme in the tissue of mice‟s liver which has inducted by aloxan, and then analyze the datas using Kolmogorov-Smirnov test and continued by Mann-Whitney test. The result of this study showed that the ethanolic extract of the faloak bark has antioxidant activity. Antioxidant activity of ethanolic extract of faloak bark by in vitro test has IC50 value 4,86 ppm, this indicated that the ethanolic extract of faloak bark include of a strong antioxidant. The result of in vivo test showed that glutathion peroxidase enzyme with the effective dose 260 mg/Kg weight of mice and the value of increase level of glutathion peroxidase enzyme is 56,10 U/mg and there is significant difference compared with the diabetic control group. Key words : faloak bark, DPPH, gutathion peroxidase, antioxidant.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: faloak bark, DPPH, gutathion peroxidase, antioxidant.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 25 Feb 2019 03:17
Last Modified: 25 Feb 2019 03:17
URI: http://repository.setiabudi.ac.id/id/eprint/1068

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